As per patent office journal dated 03/09/2021, patent number 375367 has been granted to BAYER PHARMA AKTIENGESELLSCHAFT that is titled ANTIBODY DRUG CONJUGATES (ADCS) WITH KINESIN SPINDLE PROTEIN (KSP)
The primary independent claim of this patent states a conjugate of a binder or derivative thereof with one or more active compound molecules, the active compound molecule being a kinesin spindle protein inhibitor attached to the binder via a linker L.
During the patent prosecution, the patent examiner objected to this patent under section 3(d) of the Indian Patents Act. The patent applicant responded to this objection by stating that the cited compounds are pyrazole derivatives or pyrrole derivatives. The claimed invention indicates the cytotoxic effects of claimed drug conjugates demonstrating the cytotoxicity in various cell lines, including human lung carcinoma cells, human pancreas carcinoma cells, and human breast carcinoma cells. Further, the present invention demonstrates inhibition/growth of tumors in mice treated with claimed drug conjugates, showing better efficacy than cetuximab, toxophore A, and toxophore B. Similar efficacy results of claimed conjugates are shown in other tumor models in mice. Accordingly, the claimed compounds are patentable, especially in view of the lack of comparative pyrazole derivatives or pyrrole derivatives. Therefore, the present invention does not fall under section 3(d) of the Patents Act.
This patent falls under the category of Chemical. Overall, this patent covers a conjugate of a binder or derivative thereof with one or more active compound molecules, the active compound molecule being a kinesin spindle protein inhibitor attached to the binder via a linker L.
Our team of advanced patent attorneys assists clients with patent searches, drafting patent applications, and patent (intellectual property) agreements, including licensing and non-disclosure agreements.
Advocate Rahul Dev is a Patent Attorney & International Business Lawyer practicing Technology, Intellectual Property & Corporate Laws. He is reachable at rd (at) patentbusinesslawyer (dot) com & @rdpatentlawyer on Twitter.
Quoted in and contributed to 50+ national & international publications (Bloomberg, FirstPost, SwissInfo, Outlook Money, Yahoo News, Times of India, Economic Times, Business Standard, Quartz, Global Legal Post, International Bar Association, LawAsia, BioSpectrum Asia, Digital News Asia, e27, Leaders Speak, Entrepreneur India, VCCircle, AutoTech).
Regularly invited to speak at international & national platforms (conferences, TV channels, seminars, corporate trainings, government workshops) on technology, patents, business strategy, legal developments, leadership & management.
Working closely with patent attorneys along with international law firms with significant experience with lawyers in Asia Pacific providing services to clients in US and Europe. Flagship services include international patent and trademark filings, patent services in India and global patent consulting services.
Global Blockchain Lawyers (www.GlobalBlockchainLawyers.com) is a digital platform to discuss legal issues, latest technology and legal developments, and applicable laws in the dynamic field of Digital Currency, Blockchain, Bitcoin, Cryptocurrency and raising capital through the sale of tokens or coins (ICO or Initial Coin Offerings).
Blockchain ecosystem in India is evolving at a rapid pace and a proactive legal approach is required by blockchain lawyers in India to understand the complex nature of applicable laws and regulations.
