As per patent office journal dated 25/06/2021, patent number 369491 has been granted to IBC Pharmaceuticals Inc. that is titled T Cell redirecting bispecific antibodies for treatment of disease. The primary independent claim of this patent states a T-cell redirecting complex having an anchoring domain moiety, anchored to first antibody moiety that binds to CD3, DDD (dimerization and docking domain) moiety from Protein kinase A further conjugated to second antibody moiety that binds to Trop- 2. The complex is formed after the two copies of DDD moiety forms a dimer and further binds to the anchoring domain (AD) moiety.
During the patent prosecution, the patent examiner objected to this patent under section 3(d) of the Indian Patents Act. The patent applicant responded to this objection by stating that the T-cell redirecting complex in the claimed invention is new and not known in the prior art. Moreover, even the composition comprising the said complex is new and has not been published in any prior art. Therefore, the subject matter of the claimed invention does not fall under the ambit of section 3(d) of the Patents Act.
This patent falls under the category of chemical. Overall, this patent covers the method and compositions of T cell redirecting complexes, i.e, DNL complex, having a binding site for T-cell antigen and the other binding site for an antigen/pathogen. The complex comprises an anti-CD3 and anti-CD19 bispecific antibody, targeting effector T-cells to induce T-cell-mediated cytotoxicity of cells associated with diseases like cancer, autoimmune disease or infectious disease. The co-administration of interferon-based agents comprising interferon α interferon-β, interferon-λ1, interferon-λ2 or interferonλ3 enhances this cytotoxic immune response.
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Advocate Rahul Dev is a Patent Attorney & International Business Lawyer practicing Technology, Intellectual Property & Corporate Laws. He is reachable at rd (at) patentbusinesslawyer (dot) com & @rdpatentlawyer on Twitter.
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