patent number 373162 has been granted to INDIAN INSTITUTE OF TECHNOLOGY KANPURthat is titled NANOPARTICLE-BASED DRUG DELIVERY SYSTEM FOR NICLOSAMIDE AND A COMBINATION THEREOF. The patent applicant responded to this objection by stating that section 3(d) does not apply to the present compounds and that the technical merit of the present invention is further substantiated by embodiments of the present invention. This patent falls under the category of Chemical. Overall, this patent covers a nanoparticle-based drug delivery system for Niclosamide wherein a nanoparticle-based combinatorial drug delivery system comprises a synergistic combination of Niclosamide loaded nanoparticles 15 and Doxorubicin loaded nanoparticles for leads to death of all clinical subtypes of breast cancer cells can be used for treating other cancer types as well covering multiple cancers such as colorectal cancer, prostate cancer, breast cancer, melanoma, gastrointestinal cancer, osteosarcoma, leukemia, glioblastoma, lung cancer, hepatocellular carcinoma, ovarian cancer, pancreatic cancer etc.