Patent granted in India to NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER)
Patent number 373139 has been granted to NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER) that is titled CAN IMPROVED PROCESS FOR THE PREPARATION OF SULFONYLUREAS. The primary independent claim of this patent states a process to produce compound and salts thereof by reacting a compound of the formula with an acyclic carbonate ester compound in the presence of first solvent and at an appropriate temperature to form a mixture and further extracting the mixture obtained, with an organic solvent to separate the extracts of compounds of the formula II. The patent applicant responded to this objection by stating that in the present invention, the carbamate can be prepared by reacting an amine with an acyclic carbonate ester in aqueous or aqueous-organic solvents without using any base. This patent falls under the category of Chemical. Overall, this patent covers a process for the preparation of sulfonylurea compounds of formula I as anti-diabetic agents with high purity and yield and without the use of any hazardous reagents.
