Patent number 378938 has been granted to SIMMONS William H. that is titled 4 FLUORO THIO CONTAINING INHIBITORS OF APP2 COMPOSITIONS THEREOF AND METHOD OF USE. The patent applicant responded to this objection by stating that the claimed compound does not pertain to mere forms/derivatives of known compounds. This patent falls under the category of Chemical. Overall, this patent covers a fluoro-thiol-containing compound that is capable of specifically inhibiting the enzyme, membrane-bound aminopeptidase P2 5 (APP2), whose natural substrate is bradykinin. The compound is useful as a pharmaceutical agent because by inhibiting bradykinin degradation, the compound allows endogenous bradykinin to exert its beneficial effects in the body including dilating coronary arteries, providing protective effects in the heart during myocardial ischemia/reperfusion injury, stimulating formation of new blood vessels, improving organ 10 function in chronic heart and renal disease, and improving glucose tolerance and insulin sensitivity.