Patent number 371103 has been granted to TAKEDA VACCINES INC. that is titled PARENTERAL NOROVIRUS VACCINE FORMULATIONS. During the patent prosecution, the patent examiner objected to this patent under section 3(d) of the Indian Patents Act. The patent applicant responded to this objection by stating that the claims of the present invention do not recite mere use of known substances, instead the composition with specific amounts of genogroup I Norovirus VLP and genogroup II Norovirus VLP as described in the present invention is novel per se. This patent falls under the category of Pharmaceuticals. Overall, this patent covers vaccines for Noroviruses. The present invention relates to single dose parenteral vaccines composition with monovalent Norovirus virus-like particles.